After the establishment of the Islamic Republic, Iran has always faced a wide range of comprehensive sanctions from major world powers. The United States is one of the staunch supporters of economic and political sanctions to achieve the desired goals in foreign policy, although the imposition of sanctions against Iran is not a new issue; but the new round of sanctions is designed to focus on the country's revenue sectors and weaken the value of the national currency, which has been accompanied by political pressure and greater consultation between the United States and its European allies. Economic sanctions have negative effects by creating disorderly conditions and turmoil in the economy, and subsequently increase public dissatisfaction. The main question of the research is: "How is the role of public policymaking in confronting economic sanctions against Iran analyzed and examined?" On the other hand, the effectiveness of sanctions depends on the economic structure of the target country. Given that policymakers have not yet adopted a desirable transformational approach to confronting sanctions, but by considering indicators such as adopting a development-oriented foreign policy, strengthening the government's relationship with civil society and the private sector, pursuing anti-sanctions strategies, and strengthening the knowledge-based economy, it will be able to play a more desirable role in confronting sanctions. The present study was conducted using an analytical-descriptive approach and data collection was conducted through library and document studies.