The purpose of this article was to investigate the methods of achieving the country's material interests through foreign policy in the government of Khatami and Ahmadinejad, and the study was carried out using a descriptive-analytical method. Khatami's government, by engaging with Western governments, which basically had a strong economy, provided the means to secure the country's material interests as much as possible. But the passage of time has proven that the western countries and America at the head of them, beyond their material interests, are subject to some international events and will adhere to their behavior as long as the political events suit them. Ahmadinejad's government, with the experience gained from the behavior of Western countries with Khatami's government, decided to use interaction in another way and in this way believed that the countries of South America, Africa and developing countries have potentials that can be used in Together, we can provide the material interests of the country. With this definition, it seems that the use of the diplomatic system in order to secure the material interests of the country, by both presidents with an approach to interacting with countries, was a suitable solution that could be done with a little more expert review and also to establish coordination with other domestic non-governmental organizations. Tell about more suitable successes in achieving material benefits for the country.